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Tommie Richardson, MD 



Elaine Reedy, Ph.D,

The Synergy Principle of
DA-REL is an advance formulated dietary supplement used to manage depression, anxiety, and chronic stress. DA-REL is not only an effective aid for emotional and mental health, it has a synergy of nutrients that have been clinically shown to naturally support
brain and heart health. 
Dr. Tommie Richardson spearedheaded the research and development of DA-REL with Dr. Elaine Reedy. After over 10 years of collaboration on the efficacy of nutrients in their role on health and more specifically mental health, DA-REL was manufactured in the USA. 
We like to have hands on when it comes to recommending dietary supplements to our patients, clients, and online customers. Unlike the many products that are online where there is little knowledge on how products are handled, we have done due diligence in making sure that DA-REL is formulated under good manufacture practices (GMP) and meet the specific balance of nutrients that are cited in scientific literature.  We call this balance of precise nutrient delivery, the synergy principle. 
The Synery Principle
balance of 
2020 ushered in a plethora of events that have for millions escalated emotional stress, .   stresshave escalation brought on unperiled   formulated based on the synergy principles of nutrients.  By definition, a nutrient is a substance that provides nourishment essential for growth and the maintenance of life.  On the other hand, the synergy principle of nutrients says that when two or more nutrients are balanced in their relationship, the body writes its own remedies essential to life and protection against disease.
DA-REL's synergistic properties are well researched in clinical studies. DA-REL is doctor recommended for its role in helping the body produce a plethora of neurochemicals.
Malfunction in the production of neurochemicals upset the cascade of neurotransmitters.  Stress and poor assimilation (intake and breakdown) of specific nutrients are linked to health risks.
Nutrients are vital to brain and mood health. The body needs access to nutrients in their synergy relationship.  DA-REL offers the precise balance of synergy needed to help the body feel well mentally and physically.
DA-REL is doctor recommended as an effective all natural high-quality dietary supplement. It has the synergy principle needed to manage depression, anxiety, stress, and support
brain, and heart health.

Nutrients love company, so while there is plenty of evidence that each of the key nutrients discussed and included in the formula DA-REL, folate, B 12, B6, zinc, and magnesium - work on their own to lower homocysteine. They are much, much better together. Their impact as a group is greater than the sum of all the individual effects. In other words, 1 + 1 equals 3 or 4! This is the principle of synergy.

The idea that nutrients work better in combination is not only common sense but also proven. First of all, people rarely, if ever, become deficient in just one essential nutrient. A person eating pure fruits and vegetables, nuts, or seeds is going to be deficient in a wide range of nutrients. Thus, we recommend eating a highly varied and whole food (unprocessed, unpackaged) diet, giving you the best full spectrum of nutrients. We also passionately recommend taking a high-quality, comprehensive multivitamin and mineral supplement that provides optimal amounts of all the B-vitamins, plus magnesium and zinc. You will find this in DAREL.

We have discussed how the enzymes involved in turning homocysteine either into SAMe or glutathione depend on quite a crew: Vitamins B12, B6, magnesium, and zinc. So you will need the right combination of synergistic (1+1 equals 3) nutrients. The boost in effectiveness given by synergy also means lower amounts of each key nutrient are needed at less cost to you. This is exactly what scientific research and published studies show.

While conventional medicine likes to focus on one drug for one condition (folate to lower homocysteine for example), 20% of people with high homocysteine do not respond to folate on its own. Paradoxically, there is at least one study showing that some people who take only folate have a modest increase in their homocysteine score. This was demonstrated in a published study of 304 men and women who were given either 1000 mcg or 2000 mcg of folate for three consecutive weeks.


While overall, there is s a small decrease in the average homocysteine scores, 20% of people in this study had a modest increase of 1.5 units. No obvious reason for this individual variation was given.

So, folate on its own is sometimes ineffective, but not so in combination with other homocysteine-lowering nutrients. The power of synergy is also well illustrated by a very important study from Japan involving patients with chronic kidney disease, a condition linked with very high homocysteine levels, enhanced heart attacks, and strokes. The Japanese patients were divided into three groups: One was given either folate or vitamin B 12 (in the form of methylcobalamin, the active form of B 12) alone. One group was given folate and B 12 together, and the third group was given folate, B12, and B6.

The supplements were administered for three weeks. The results of this remarkable study are:

  • Supplementing with folate alone resulted in a 7.3% reduction in homocysteine (good, but not nearly good enough).

  • Supplementing with vitamin B 12 alone resulted in an 18.7% reduction in homocysteine (better, but still not good enough).

  • Supplementing with folate plus vitamin B12 resulted in a 57.4% reduction in homocysteine.

  • Supplementing with folate, vitamin B 12, and vitamin B6 resulted in a 59.9% reduction in homocysteine.

Notice that this study has revealed two very important principles. First, the more nutrients provided, the greater the reduction in homocysteine, and secondly, the right combination of nutrients at the right dose can more than have half your homocysteine level score in as little as three weeks. This study shows that adding in vitamin B6 provides only a small additional benefit; however, we question the lack of zinc, all of which are needed to activate vitamin B6.

An analysis of 12 other trials involving a total of 1,114 people came to a similar conclusion. The researchers found that folate on its own could lower homocysteine at 25%. Adding in vitamin B 12 produced a further 7% reduction, giving a 32% reduction overall. On the other hand, they did not find a significant further reduction with the addition of very low doses of vitamin B6 (averaging 16.5 mg).

While vitamin B6 may not always be as powerful as a homocysteine buster as folate or vitamin B 12, we think that larger amounts of vitamin B6 including activated B6 as P-5-E, together with zinc would be more effective; then of course, last, but not least, in a healthy diet that contains plenty of fruits and vegetables.